Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests
Section I: Introduction to Molecular Testing Chapter 1. Basic Concepts in Molecular Pathology-Introduction to Molecular Testing in Human Disease Chapter 2. Laboratory Approaches in Molecular Pathology-The Polymerase Chain Reaction Chapter 3. Next-Generation Sequencing in the Clinical Laboratory Chapter 4. Automation of the Molecular Diagnostic Laboratory Section II: Molecular Testing in Infectious Disease Chapter 5. Molecular Testing for Human Imunodeficiency Virus Chapter 6. Molecular Testing in Hepatitis Virus Related Disease Chapter 7. Molecular Testing for Human Papillomaviruses Chapter 8. Molecular Testing for Herpes Viruses Chapter 9. Molecular Testing for Parvoviruses Chapter 10. Molecular Testing for Polyomaviruses Chapter 11. Molecular Testing for Respiratory Viruses Chapter 12. Molecular Testing for Diseases Associated with Bacterial Infections Chapter 13. Agents Associated with Sexually Transmitted Infections Chapter 14. Molecular Methods for Healthcare-Acquired Infections Chapter 15. Molecular Testing in Emerging Infectious Diseases Section III: Molecular Testing in Genetic Disease Chapter 16. Noninvasive Prenatal Screening (NIPS) for Fetal Aneuploidies Chapter 17. Molecular Testing in Inherited Cardiomyopathies Chapter 18. Molecular Diagnostics for Coagulopathies Chapter 19. Molecular Diagnosis of Cystic Fibrosis Chapter 20. Molecular Testing in Hemochromatosis Section IV: Molecular Testing in Oncology Chapter 21. Molecular Testing in Breast Cancer Chapter 22. Molecular Pathology of Prostate Cancer Chapter 23. Molecular Testing in Lung Cancer Chapter 24. Molecular Testing in Colorectal Cancer Chapter 25. Molecular Pathology and Testing in Melanocytic Tumors Chapter 26. Molecular Testing for Glioblastoma Chapter 27. Molecular Testing in Pancreatic Cancer Chapter 28. Molecular Testing in Gynecologic Cancer Chapter 29. The Emerging Genetic Landscape in Renal Cell Carcinoma Chapter 30. Molecular Testing in Thyroid Cancer Chapter 31. Molecular Testing in Pediatric Cancers Section V: Molecular Testing in Hematopathology Chapter 32. Molecular Testing in Chronic Myelogenous Leukemia Chapter 33. Molecular Testing in Acute Myeloid Leukemia Chapter 34. Molecular Testing in Myeloproliferative Neoplasms Chapter 35. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment Section VI: Molecular Testing in Personalized Medicine Chapter 36. Personalized Medicine in Cardiovascular Disease Chapter 37. Personalized Medicine for Coagulopathies Chapter 38. Personalized Medicine for Hepatitis C Virus Chapter 39. Personalized Medicine in Cancer Treatment Section VII: The Future of Molecular Testing Chapter 40. Imaging Mass Spectrometry in Clinical Pathology Chapter 41. Whole Genome Sequencing in the Molecular Pathology Laboratory
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